📌 TOPINDIATOURS Eksklusif ai: People Jabbing Themselves With Black Market “GLP-3”

Some people are hitting a weight loss plateau with GLP-1 agonist drugs like Ozempic, so they’re turning to a stronger variety that promises even more dramatic weight loss — up to more than 70 pounds in some instances, The Atlantic reports.

There’s a small wrinkle: the US Food and Drug Administration has yet to officially approve this medication — technically called retatrutide but cheekily nicknamed a “GLP-3” by users — because it’s still in clinical trials. So the market for it is black, or at least severely grey, with shady overseas companies exploiting a legal loophole to get around regulatory barriers.

In other words, everyone taking retatrutide is basically taking part in an unregulated experiment that could have disastrous results. Sure, you can effortlessly melt off the pounds with the synthetic peptide, but some users have reported disturbing side effects — such as dysesthesia, when your body processes normal sensations but you perceive them as painful, similar to the nerve pain diabetics feel in their feet.

In the grand scheme of things, “GLP-3” users are part of a burgeoning group of people who have turned to foreign-made drugs, many other peptides that are also lacking federal approval. These substances, often manufactured in China, have become wildly popular in recent years for their purported anti-aging and longevity boosting potential, among other miraculous claims.

Companies that sell these drugs are able to skirt federal regulations by writing all over their website that the compounds are not for human consumption and are instead meant for research lab purposes — advice that users are pretty clearly not following.

“All of this stuff just scares the crap out of me,” Randy Seeley, a University of Michigan medical professor and GLP-1 agonist expert, told The Atlantic in reference to the unknown side effects of gray market drugs.

One danger with these drugs, Seeley said, is that their formulations aren’t known and they have the potential to be contaminated with bacteria and other substances. (To allay those concerns, some companies post lab results attesting to the purity of their products.)

Of course, everybody thinks their dealer is an exception.

“There’s a lot of people who just get these things and shoot them,” Marco, a retatrutide user who has bought the drug from what he considers trusted sources, told The Atlantic. “I don’t judge them in any way, but I think those people are out of their minds.”

Injecting GLP-1 agonist drugs into the human body boosts the levels of hormones GLP-1 and GIP, which trigger the release of insulin into your bloodstream. Retatrutide does that and more: it mimics another hormone, glucagon, found in the pancreas. This addition further revs up people’s metabolism, making them lose more weight compared to Ozempic and other GLP-1 agonist drugs.

Once clinical trials are done, FDA is expected to approve retatrutide, which will no doubt be a bestseller and make its manufacturer, Eli Lilly, even wealthier.

But even if it’s given the green light, it’s not a guarantee that the demand in the gray market will dissipate, especially if normies find the price too weighty to bear.

More on weight loss drugs: Low Doses of Ozempic-Like Drug Can Counteract Aging in Older Mice, Study Finds

The post People Jabbing Themselves With Black Market “GLP-3” Drugs appeared first on Futurism.

🔗 Sumber: futurism.com

📌 TOPINDIATOURS Update ai: Alzheimer’s Fully Reversed in Mice, Scientists Say Hari

A team of American scientists claim they have done something miraculous: they “cured” lab mice suffering from Alzheimer’s disease, which has robbed more than seven million Americans, typically 65 years old and up, of their identity and cognitive ability.

The researchers achieved this feat by administering the rodents with the powerful compound P7C3-A20, which they announced in a new paper in the journal Cell Reports Medicine. Scientists from Ohio’s Case Western Reserve University (CWRU), University Hospitals, and the Louis Stokes Cleveland VA Medical Center undertook the study.

“The key takeaway is a message of hope — the effects of Alzheimer’s disease may not be inevitably permanent,” said Andrew A. Pieper, the study’s principal investigator and a CWRU neuroscience professor, in a statement about the research. “The damaged brain can, under some conditions, repair itself and regain function.”

This research is part of a growing wave of very promising lab studies that point to a tantalizing future where Alzheimer’s and other neurological issues could be a thing of the past. Besides this P7C3-A20 research, others have scored remarkable lab results using different compounds and treatments.

This has made normally cautious scientists so excited that they are making bold predictions. University of Edinburgh neuroscience professor Tara Spires-Jones, who wasn’t part of this P7C3-A20 study, told the BBC this month she thinks scientists are closer than ever to a “truly life-changing” treatment — in as little as five to 10 years; instead of a slow death where people lose themselves, she forecasts that new tests will detect the condition early and innovative treatments will “really make your life normal.”

Scientists are also closer to understanding what causes Alzheimer’s, which seems to be sparked by different factors such as genetics, environment and other stressors — which means that future patients may receive personalized cocktail of anti-Alzheimer’s treatment and drugs suited for their own situation.

Regardless of the cause, previous research has suggested that Alzheimer’s is a form of inflammation. That means lessening or zeroing out inflammation in the brain would be key rather than managing symptoms.

In the P7C3-A20 study, the scientists focused on the impact of the crucial molecule NAD+, a coenzyme important for driving cellular metabolism and which decreases as we age, according to the study. Patients with Alzheimer’s suffer from a significant decrease of NAD+ in the brain, and hence their brain cells have trouble maintaining normal functionality, staving off inflammation, and canceling other physical hallmarks of the disease.

For the study, the team first took two types of lab mice that have been genetically bred to be predisposed to Alzheimer’s; one cohort had mutations for the amyloid protein and the other had tau protein mutations. Both proteins are important to cellular function, but they can become dangerous if they accrete in the brain in the form of amyloid plaques and tau tangles — causing a breakdown in normal cellular processes.

The team injected P7C3-A20 into both mice cohorts at two months of age, later finding out that this treatment successfully prevented them from developing the disease. But the big news was when they injected the compound into another batch of lab mice, who were suffering from a relatively advanced stage of Alzheimer’s at six months of age; after getting injections, these mice completely recovered their cognitive ability and NAD+ levels were restored to homeostasis leve;s

“We were very excited and encouraged by our results,” said Pieper in the statement. “Restoring the brain’s energy balance achieved pathological and functional recovery in both lines of mice with advanced Alzheimer’s. Seeing this effect in two very different animal models, each driven by different genetic causes, strengthens the new idea that recovery from advanced disease might be possible in people with AD when the brain’s NAD+ balance is restored.”

What’s also good about this study is that P7C3-A20 offers an alternative pathway to boosting NAD+ levels versus taking over-the-counter chemical precursors for NAD+, which can can raise NAD+ to such toxic levels that people could develop cancer, Pieper said. Supplements to boost NAD+ are just a click away on your cellphone, which should be worrying for anybody concerned about cancer.

The team wants to move to human clinical trials but some people are clearly not waiting; if you search online on how to obtain P7C3-A20 for yourself, numerous websites selling vials of the compound will pop up.

More on Alzheimer’s disease: Scientists Identify Possible Game Changing Treatment for Alzheimer’s Disease That Could Control It Like High Cholesterol

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🔗 Sumber: futurism.com